Wednesday, January 12, 2011

My Latest Genome SNP report from DeCodeMe

This post is an update on my SNP genome scan report in which there has been a few developments. It came about because my dad (Bob Marshall) had his 80th birthday last week and we made a detailed report on his ancestry based on DeCodeMe. By the Y-chromosome he was related to Somerled the Viking-Scottish 12th century king (as are millions of other caucasians). However, I noted the high risk he has for macular degeneration (5x, 46%). This rang a bell because his grandmother (Jessie Boneham) went blind after "she had her cataracts removed but the operation didn't work" suggesting retinal disease after age 85 years. Anyway I looked again at my age related macular degeneration risk and see a lesser but elevated risk (2.88x, 23%). Last month my eye exam was normal except for early arcus senilis and slight refraction problems. I'll continue with a two yearly check. This year I decided to seriously attend to my blood pressure (erratic and about 20mm above ideal levels if not treated) and also my cholesterol. My SNP risks reflect a 50% risk of hypertension, as well as diabetes, obesity and heart attack (although modestly elevated). Good news is that my risk of muscle damage from my statin is low so I can take these with impunity. My recent blood pressure readings are graphed in one of the documents on the web site. An episode of angioedema caused me to change my ACE inhibitor to an ACE receptor blocker and so far I have not had any more side effects.

You can read my full SNP report plus other health reports here: . I also include an AVI file showing a movie of my coronary calcium CT scan and you can go into the directory below to see my actual raw SNP data in case you want to research it. I don't know what use this information is but I do want to hold true to my idea of a public health record. More and more people care less and less about this type of data - its becoming so common.

What else is new? Well, I am saving up to have my total genome done. I would also like to do my whole family, but the Western Australian DNA bank refuses to store the DNA at present. They are so precious that they only do storage for bona-fide research projects, not for people like me who are just exploring their own family. So I may just keep it frozen in the back of my -80C refrigerator at the H.pylori Research Lab.